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Centrifuge in Pharma is an indispensable device in the pharmaceutical industry. Proper use and maintenance of the centrifuge in pharma can not only prolong the lifespan of the equipment but also ensure the accuracy and safety of experiments. This article will detail how to correctly use and maintain a centrifuge in pharma.
During the high-speed operation of a centrifuge in pharma, even minor operational errors can lead to severe damage. Therefore, understanding safety precautions and correct operation is crucial. Below are safety operation guidelines for using a centrifuge in pharma:
Before starting the centrifuge in pharma, check the following:
Ensure the rotor and other attachments are normal
Check if the rotor is correctly placed on the spindle
Ensure the central nut or cap on the rotor body is not loose
Check for deformation or cracks in the centrifuge bottles/ tubes
Ensure the balanced weight of centrifuge bottles/ tubes
When using a centrifuge in pharma, centrifuge bottles and tubes need to be weighed and balanced on a scale. Adjust the amount of material to make the weights of bottles or tubes as equal as possible, not exceeding the allowed maximum imbalance, which is generally 2 grams. Place the centrifuge bottles or tubes symmetrically inside the rotor.
Before starting the centrifuge in pharma, ensure the centrifuge chamber is clean and free of debris. Do not open the centrifuge lid or move the centrifuge during operation. Avoid placing any items on the lid to prevent damage if the lid opens automatically.
After centrifugation, wait for the rotor to completely stop before pressing the stop button to open the lid and remove the centrifuge bottles/ tubes. Handle with care to prevent precipitated substances from becoming turbid due to vibrations.
During the use of a centrifuge in pharma, if a fault alarm appears on the screen, immediately stop the machine or cut off the power; if the centrifuge vibrates significantly, it indicates an imbalance. If there is a noise of breaking centrifuge bottles or tubes, stop the use and check. Ensure to clean up any fragments before using again.
After use, clean the equipment and cut off the power. After each use, remove the rotor and clean the centrifuge chamber with a cotton cloth and dry it.
To ensure the long-term stable operation of a centrifuge in pharma, regular maintenance is essential. Here are some key maintenance steps:
After each use, clean the rotor with a neutral detergent and dry it with a cotton cloth. Store it in a dry and ventilated place. The centrifuge chamber should also be cleaned to prevent water or residue buildup.
If the centrifuge in pharma is unused for a long time, clean the centrifuge chamber and place desiccants inside to absorb moisture, preventing rust on the drive shaft. Apply a small amount of lubricant grease on the motor shaft.
The control panel surface must be kept clean. Clean the control panel with a dry soft cloth only and keep it away from water to prevent damage to the control circuit board.
Avoid hitting or damaging the taper surface of the drive shaft. Before inserting the rotor, clean the drive shaft and rotor taper hole with a soft cloth, and apply a small amount of medical Vaseline or other grease.
Do not place rotors, centrifuge test bottles or hanging cups, and other tools on the centrifuge lid or head to prevent scratches and damage. Clean the outer surface of the lid and chassis with a soft cloth and neutral detergent only. Do not use strong corrosive disinfectants (such as 84 disinfectant) to disinfect the centrifuge.
By following the above usage and maintenance tips, pharmaceutical companies can ensure the high-efficiency operation and long-term stability of centrifuge in pharma, providing solid assurance for drug production.